Analysis of translational inhibition by basic amino acid repeat

Research Project

Project/Area Number	20790095
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Biological pharmacy
Research Institution	The University of Tokyo
Principal Investigator	AKIMITSU Nobuyoshi The University of Tokyo, アイソトープ総合センター, 准教授 (40294962)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords	翻訳 / 遺伝子 / ゲノム
Research Abstract	Bio-infomatic analysis revealed that human genome encode 267 genes which harbor basic amino acid repast. This suggests that 0.7% of all human genes are regulated by basic amino acid repast-mediated translational repression. To investigate this idea, several reporter genes encoding basic amino acid repast sequence were constructed and tested. Moreover, we found that TAT gene encoded in HIV genome also encodes basic amino acid repast. However, basic amino acid repast of TAT gene is not involved in translational repression-mediated gene regulation.

Report

(3 results)