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Analysis of translational inhibition by basic amino acid repeat

Research Project

Project/Area Number 20790095
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionThe University of Tokyo

Principal Investigator

AKIMITSU Nobuyoshi  The University of Tokyo, アイソトープ総合センター, 准教授 (40294962)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords翻訳 / 遺伝子 / ゲノム
Research Abstract

Bio-infomatic analysis revealed that human genome encode 267 genes which harbor basic amino acid repast. This suggests that 0.7% of all human genes are regulated by basic amino acid repast-mediated translational repression. To investigate this idea, several reporter genes encoding basic amino acid repast sequence were constructed and tested. Moreover, we found that TAT gene encoded in HIV genome also encodes basic amino acid repast. However, basic amino acid repast of TAT gene is not involved in translational repression-mediated gene regulation.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (4 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro.2010

    • Author(s)
      Tani H, Fujita O, Furuta A, Matsuda Y, Miyata R, Akimitsu N, Tanaka J, Tsuneda S, Sekiguchi Y, Noda N.
    • Journal Title

      Biochem Biophys Res Commun. 393

      Pages: 131-136

    • Related Report
      2009 Final Research Report
  • [Journal Article] Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro2010

    • Author(s)
      Tani H, Fujita O, Furuta A, Matsuda Y, Miyata R, Akimitsu N, Tanaka J, Tsuneda S, Sekiguchi Y, Noda N.
    • Journal Title

      Biochem Biophys Res Commun 393

      Pages: 131-136

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput screening assay of hepatitis C virus helicase inhibitors using fluorescence-quenching phenomenon.2009

    • Author(s)
      Tani H., Akimitsu N., Fujita O., Matsuda Y., Miyata R., Tsuneda S., Igarashi M., Sekiguchi Y., Noda N.
    • Journal Title

      Biochem Biophys Res Commun. 379

      Pages: 1054-1059

    • Related Report
      2009 Final Research Report
  • [Journal Article] High-throughput screening assay of hepatitis C virus helicas e inhibitors usinc fluorescence?auenchina phenomenon2009

    • Author(s)
      谷英典
    • Journal Title

      Biochem Biophys Res Commun. 379

      Pages: 1054-1059

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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