Preparation and evaluation of diaminopimelic acid derivatives as multifunctional pharmaceutical materials
| Project/Area Number |
20790104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
SAITO Yukako Tohoku Pharmaceutical University, 薬学部, 助手 (30364409)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 有機化学 / アミノ酸 / クロスメタセシス反応 / 生理活性 / 自然免疫 |
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| Research Abstract |
A naturally occurring amino acid, meso-diaminopimelic acid (meso-DAP) is also an essential component of the peptidoglycan of most pathogenic bacteria and has been studied extensively on the innate immune response. We describe (1) straightforward synthesis of meso-DAP (2) functional group-containing meso-DAP derivatives (3) synthesis of meso-DAP-containing peptides.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Chemoselective2010
Author(s)
Saito, Y., Yoshimura, Y., Takahata, H.
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Journal Title
O-tert-butoxycarbonylation of phenols using 6,7-dimethoxyisoquinoline as a novel organocatalyst, Tetrahedron Lett. 51
Pages: 6915-6917
Related Report
Peer Reviewed
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