Clarification of the neuro-protective effect of ginkgolides using it's carbon-11 derivatives
| Project/Area Number |
20790109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Drug development chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ISHII Hideki The Institute of Physical and Chemical Research, 分子イメージング創薬化学研究チーム, 副チームリーダー (80425610)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | イチョウ / イチョウ葉抽出液 / ギンコライド類 / 陽電子放射断層画像撮影法(PET法) / ジテルペノイド / PAF受容体 / PETプローブ / 神経変性疾患 / GABA_A受容体 / ジテルぺノイドPAF受容体 |
|---|
| Research Abstract |
A ginkgo biloba, which is the effective for treatment of the decline of the memory, is treated as medical supplies in a large number of countries such as Germany or France, and is sold as a health food in Japan. In order to elucidate of the reaction mechanism of the cerebral nerve cytoprotection of the ginkgo biloba, I aimed at the synthesis of ginkgolide derivatives which is labelled with a short-lived radioactive compound. The synthesis of ginkgolie derivatives with the cerebral nerve cytoprotection and the 18F- fluorine derivative was achieved.
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Report
(3 results)
Research Products
(9 results)
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[Presentation] 15R-TIC-Meを用いた薬物動態PETイメージングの有用性評価2009
Author(s)
高島忠之, 田中雅彰, 鴫原良仁, 安宅鈴香, 伊集院良祐, 石井英樹, 和田康弘, 土居久志, 前田和哉, 杉山雄一, 渡辺恭良
Organizer
第49回日本核医学会学術総会
Place of Presentation
旭川市
Related Report
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