Biochemical analysis of extracellular matrices and their degradation enzymes in methylmercury-induced neurotoxicity
| Project/Area Number |
20790115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Environmental pharmacy
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| Research Institution | Hokuriku University |
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Principal Investigator |
SHUO Takuya Hokuriku University, 医科学研究所, 特任研究員 (90399006)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | メタロプロテアーゼ / プロテオグリカン / メチル水銀 / 神経細胞毒性 / 水俣病 / 細胞外環境 / 神経細胞周囲網 |
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| Research Abstract |
To clarify the molecular mechanism of neurotoxicity induced by methylmercury, we investigated extracellular matrices and their degradation enzymes. In this study, we showed that methylmercury-activated matrix metalloproteinase MMP-2 cleaved neurocan, an extracellular proteoglycan. Then, we also indicated the occurrence of a soluble form of neuroglycan C, a transmembrane proteoglycan in rodent brain.
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Report
(3 results)
Research Products
(5 results)
