| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Cadmium, a ubiquitous heavy metal, is an important industrial and environmental pollutant that can target the vascular endothelium. In this study, we investigated the participation of Nrf2 in cellular response to cadmium and protection against this metal in bovine aortic endothelial cells. Exposure of the cells to cadmium resulted in Nrf2 activation followed by up-regulated expression of antioxidant proteins. We found that the Nrf2/Keap1 system serves as a defense mechanism against cadmium toxicity through a positive regulation of metallothionein gene in vascular endothelial cells.
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