| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
The aim of this study is to investigate the mechanism for the inhibitory effect of 3-methylcholanthrene (3MC) on 5α-dihydrotestosterone (DHT)-dependent transcriptional activation in human prostate cancer LNCaP cells. The results in this study suggest that complex formation between AhR and androgen receptor (AR), and binding of AhR to the AhR-binding site in the transcriptional regulatory region of androgen-regulated gene, a prostate specific antigen gene, play important roles in the inhibitory effect of 3MC on DHT-dependent transcriptional activation.
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