| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In response to iron starvation, nosocomial Acinetobacter baumannii produces the siderophore, acinetobactin, and can transport acinetobactin-bound iron into the periplasm via its specific outer membrane receptor, BauA. In this study, I showed that A. baumannii was also capable of utilizing a variety of xenosiderophores produced by other microorganism as an iron source. Biofilms consist of bacteria attached to surfaces and encased in a polymeric matrix. I showed that iron and acinetobactin appear to mediate the control of biofilm formation.
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