Screening of Norovirus and Sapovirus receptor and establishment of viral infection system

• Project/Area Number: 20790125
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental pharmacy
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: OKA Tomoichiro National Institute of Infectious Diseases, ウイルス第2部, 主任研究官 (50356242)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 微生物 / 感染症学 / ウイルス / 感染症

Research Abstract

A cell-based assay system that allow monitoring of feline calicivirus protease activity has been established using the principle of bioluminescence resonance energy transfer (BRET).

Research Products

• [Journal Article] Distinct genotype and antigenicity among genogroup II sapoviruses (2009)
  • Author(s): O k a T, Miyashita K, Katayama K, Wakita T, Takeda N.
  • Journal Title: Microbiology and Immunology 53(7) Pages: 417-420
• [Journal Article] Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins. (2009)
  • Author(s): O k a T, Yokoyama M, Katayama K, Tsunemitsu H, Yamamoto M, Miyashita K, Ogawa S, Motomura K, Mori H, Nakamura H, Wakita T, Takeda N, Sato H.
  • Journal Title: Virology. 394(1) Pages: 119-129
• [Journal Article] Structural and biological constraints on diversity of regions immediately upstream of cleavage sites in calicivirus precursor proteins. (2009)
  • Author(s): Oka T., et al.
  • Journal Title: Virology 394(1) Pages: 119-129
  • Peer Reviewed
• [Journal Article] Distinct genotype and antigenicity among genogroup II sapoviruses (2009)
  • Author(s): Oka T., et al.
  • Journal Title: Microbiology and Immunology (印刷中)
  • NAID: 10027687045
  • Peer Reviewed
• [Presentation] バイオセンサー発現細胞を用いたネコカリシウイルス感染検出系の構築 (2009)
  • Author(s): 岡智一郎、高木弘隆、遠矢幸伸、武田直和、脇田隆字、片山和彦
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 神奈川
  • Year and Date: 2009-12-12
• [Presentation] バイオセンサー発現細胞を用いたネコカリシウイルス感染検出系の構築 (2009)
  • Author(s): 岡智一郎, 他
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-12-12
• [Presentation] カリシウイルス増殖阻害物質スクリーニング系の構築 (2009)
  • Author(s): 岡智一郎、高木弘隆、遠矢幸伸、武田直和、脇田隆字、片山和彦
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2009-10-27
• [Presentation] カリシウイルス増殖阻害物質スクリーニング系の構築 (2009)
  • Author(s): 岡智一郎, 他
  • Organizer: 第57回日本ウイルス学会学術集会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2009-10-27
• [Presentation] BRETを用いたネコカリシウイルスプロテアーゼ活性検出系の構築 (2009)
  • Author(s): 岡智一郎、高木弘隆、遠矢幸伸、片山和彦、脇田隆字、武田直和
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-27
• [Presentation] BRETを用いたネコカリシウイルスプロテアーゼ活性検出系の構築 (2009)
  • Author(s): 岡智一郎, 他
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2009-03-27
• [Presentation] Substrate specificities of calicivirus-encoded 3C-like proteases (2008)
  • Author(s): Oka T, Yokoyama M, Katayama K, Yamamoto M, Miyashita K, Ogawa S, Motomura K, Tsunemitsu H, Wakita T, Sato H, Takeda N
  • Organizer: The Forum of the Network of research Centerson Infectious Diseases
  • Place of Presentation: ベトナムハノイ
  • Year and Date: 2008-10-06
• [Presentation] Substrate specificities of calicivirus-encoded 3C-like proteases (2008)
  • Author(s): Oka T., et al.
  • Organizer: The Forum of the Network of research Centers on Infectious Diseases
  • Place of Presentation: ベトナム ハノイ(National Institute of Hygiene and Epidemiology (NIHE))
  • Year and Date: 2008-10-06