The strategy to avoid the side effect of lipid-lowering agents
| Project/Area Number |
20790126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
KOBAYASHI Masaki Hokkaido University, 大学院・薬学研究院, 助教 (70431319)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 薬学 / 臨床 / 薬物相互作用 / トランスポータ / スタチン / ABCトランスポータ / LXR / 発現調節 / 高脂血症 / 肝臓 / 胆汁中排泄 |
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| Research Abstract |
In this study, we focused on a nuclear receptor, LXR (liver X receptor) and examined the effect of statins, lipid-lowering agents, on LXR function in HepG2 cells and the rat liver. Therefore this study can lead to precise drug therapy of hyperlipidemia.
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Report
(3 results)
Research Products
(6 results)
