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Characterization of ribavirin uptake systems in hepatocytes and renal tubular cells

Research Project

Project/Area Number 20790128
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionChiba University

Principal Investigator

FURIHATA Tomomi  Chiba University, 大学院・薬学研究院, 助教 (80401008)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords薬剤反応性 / 薬学 / 抗生物質 / リバビリン / C型肝炎 / 核酸トランスポーター / 種差 / 個人差
Research Abstract

The purpose of this study was to characterize the major ribavirin uptake transporter(s) in human hepatocytes or renal tubular cells. The results showed that equilibrative nucleoside transporter 1 (ENT1) was exclusively involved in ribavirin uptake in human hepatocytes and that the levels of the uptake activity were different among hepatocytes. On the other hand, the results suggest that concentrative nucleoside transporter 3 (CNT3), which was abundantly expressed in human renal proximal tubular cells, would be responsible for renal re-absorption of ribavirin. Genetic or environmental factors that alter the levels of function or expression of ENT1 and CNT3 should be determined in future study.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (19 results)

All 2010 2009 2008 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (15 results)

  • [Journal Article] Characterization of ribavirin uptake systems in human hepatocytes.2010

    • Author(s)
      Fukuchi Y, Furihata T, Hashizume M, Iikura M, Chiba K
    • Journal Title

      J. Hepatol. 52(4)

      Pages: 486-92

    • NAID

      130004639488

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Striking species-difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.

    • Author(s)
      Furihata T, Fukuchi Y, Iikura M, Hashizume M, Miyajima A, Nagai M, Chiba K
    • Journal Title

      Antimicrob Agents Chemother. 2010(in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of ribavirin uptake systems in human hepatocytes

    • Author(s)
      Fukuchi Y, Furihata T, Hashizume M, Iikura M, Chiba K.
    • Journal Title

      Journal of Hepatology (印刷中)

    • NAID

      130004639488

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striking species-difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes

    • Author(s)
      Furihata T, Fukuchi Y, Iikura M, Hashizume M, Miyajima A, Nagai M, Chiba K.
    • Journal Title

      Antimicrobial Agents and Chemotherapy (掲載確定)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] SLC29A1遺伝子の新規mRNA isoforms と新規プロモーター領域の同定2010

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] SLC29A1遺伝子の新規mRNA isoforms と新規プロモーター領域の同定2009

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of ribavirin uptake system in human hepatocytes2009

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰 美里、千葉寛
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] A species difference in hepatic SLC28A2 gene expression in mice, rats and humans2009

    • Author(s)
      上原基浩、降幡知巳、福地由希菜、飯倉南、橋詰美里、宮嶋篤志、千葉寛
    • Organizer
      第24回日本薬物動態学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] ヒト肝細胞におけるリバビリン取り込み機構の解析2009

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第4回トランスポーター研究会
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2009-05-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] c型肝炎治療薬リバビリンのヒト肝取り込みトランスポーターの同定とその遺伝子発現量の個人差2009

    • Author(s)
      降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第129回日本薬学会
    • Place of Presentation
      京都国際会議場(京都)
    • Year and Date
      2009-03-28
    • Related Report
      2009 Final Research Report
  • [Presentation] C型肝炎治療薬リバビリンのヒト肝取り込みトランスポーターの同定とその遺伝子発現量の個人差2009

    • Author(s)
      降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 抗がん剤の薬効発現を規定するSLC29A1遺伝子は組織特異的プロモーターにより制御される2009

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] マウス・ラット・ヒト肝細胞におけるリバビリントランスポートシステムの解析およびその種差2009

    • Author(s)
      福地由希菜、降幡知巳、千葉寛
    • Organizer
      第42回日本痛風・核酸代謝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-02-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヒトSLC29A1遺伝子の新規5'-UTRmRNAバリアントの同定と選択的プロモーターによる組織特異的発現機構2008

    • Author(s)
      福地由希菜、降幡知巳、橋詰美里、千葉寛
    • Organizer
      第31回日本分子生物学会年会第81日本生化学会大会・合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] SLC29A1遺伝子の発現は組織選択的プロモーターにより制御される2008

    • Author(s)
      飯倉南、降幡知巳、福地由希菜、橋詰美里、千葉寛
    • Organizer
      第2回トランスポーター研究会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2008-12-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肝におけるリバビリントランスポーターの同定・種差・およびヒトにおけるmRNA発現レベルの個人差2008

    • Author(s)
      福地由希菜、降幡知巳、橋詰美里、千葉寛
    • Organizer
      第23回日本薬物動態学会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-30
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] マウス、ラットおよびヒトにおけるc型肝炎治療薬リバビリン肝取り込みに寄与する核酸トランスポーターの同定2008

    • Author(s)
      福地由希菜、降幡知巳、橋詰美里、千葉寛
    • Organizer
      第3回トランスポーター研究会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identificatio of Nucleoside transporters involved in the hepatic uptake of ribavirin in mice, rats, and humans.2008

    • Author(s)
      Yukina Fukuchi, Tomomi Furihata, Misato Hashizume, Kan Chiba
    • Organizer
      2nd Asian-Pasific ISSX meeting
    • Place of Presentation
      Shanghai
    • Year and Date
      2008-05-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Identificatio of Nucleoside transporters involved in the hepatic uptake of ribavirin in mice, rats, and humans2008

    • Author(s)
      Yukina Fukuchi, Tomomi Furihata, Misato Hashizume, Kan Chiba
    • Organizer
      2nd Asian-Pasific ISSX meeting
    • Place of Presentation
      Shanghai
    • Year and Date
      2008-05-12
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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