Development of new therapy of steatohepatitis by Clostridium Butyricum

• Project/Area Number: 20790131
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Medical pharmacy
• Research Institution: Kanazawa University
• Principal Investigator: NAGATA Naoto Kanazawa University, 薬学系, 助教 (70456408)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 脂肪肝炎 / 薬物療法 / 脂質代謝 / 単鎖脂肪酸 / 酪酸 / 脂肪酸β酸化 / 腸内細菌 / プロバイオティクス / マクロファージ / AMPキナーゼ / 炎症 / 線維化 / 脂肪酸酸化

Research Abstract

We tested to treat atherogenic-diet (high cholesterol diet) induced steatohepatitis in mice by Clostridium Butyricum. After 4, 8, 16, and 32 weeks treatment, the atherogenic diet-induced steatosis, inflammation, and fibrosis were improved in the mice liver. We demonstrated that butyrate up-regulates fatty acid beta oxidation via activation AMP activated protein kinase and histone acetylation in vitro. Clostridium Butyricum may improve non-alcoholic steatohepatitis.

Research Products

• [Presentation] 腸内細菌由来の生理活性物質である短鎖脂肪酸はAMPキナーゼを活性化させる、中 川ゆうみ (2009)
  • Author(s): 長田直人, 澤本一樹, 太田嗣人, 横山将嘉, 高山浩昭, 熊崎雅史, 野田浩代, 北出紘規, 松本優香子, 御簾博文, 篁俊成, 金子周一, 宮本謙一
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: ホテルNCB、大阪
  • Year and Date: 2009-05-22