| Project/Area Number |
20790131
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
NAGATA Naoto Kanazawa University, 薬学系, 助教 (70456408)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脂肪肝炎 / 薬物療法 / 脂質代謝 / 単鎖脂肪酸 / 酪酸 / 脂肪酸β酸化 / 腸内細菌 / プロバイオティクス / マクロファージ / AMPキナーゼ / 炎症 / 線維化 / 脂肪酸酸化 |
|---|
| Research Abstract |
We tested to treat atherogenic-diet (high cholesterol diet) induced steatohepatitis in mice by Clostridium Butyricum. After 4, 8, 16, and 32 weeks treatment, the atherogenic diet-induced steatosis, inflammation, and fibrosis were improved in the mice liver. We demonstrated that butyrate up-regulates fatty acid beta oxidation via activation AMP activated protein kinase and histone acetylation in vitro. Clostridium Butyricum may improve non-alcoholic steatohepatitis.
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