IDENTIFICATION OF KEY FACTORS IN CISPLATIN-INDUCED NEPHROTOXICITY BY MICROARRAY ANALYSIS USING THE ISOLATED RENAL TUBULES
| Project/Area Number |
20790133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
YONEZAWA Atsushi Kyoto University, 医学研究科, 助教 (90452341)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 医療薬剤学 / 薬学 / マイクロアレイ / トランスポータ / 腎臓 / シスプラチン / 毒性学 |
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| Research Abstract |
Kidney consists of several renal segments. To clarify the gene expression profile in the renal tubule, which is the origin of cisplatin-induced nephrotoxicity, microarray analysis using the isolated tubules was carried out. At first, we confirmed that this experimental method reflected the tubular gene expression. In the isolated tubules of cisplatin-treated rats, the gene expression of chemokines was elevated. Chemokines are suggested to be the key factors of the renal tubular genes in cisplatin-induced nephrotoxicity.
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Report
(3 results)
Research Products
(20 results)
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[Journal Article] Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients.2010
Author(s)
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, Inui K
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Journal Title
Pharmacogenet Genomics. 20(2)
Pages: 135-138
Related Report
Peer Reviewed
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