| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Kidney consists of several renal segments. To clarify the gene expression profile in the renal tubule, which is the origin of cisplatin-induced nephrotoxicity, microarray analysis using the isolated tubules was carried out. At first, we confirmed that this experimental method reflected the tubular gene expression. In the isolated tubules of cisplatin-treated rats, the gene expression of chemokines was elevated. Chemokines are suggested to be the key factors of the renal tubular genes in cisplatin-induced nephrotoxicity.
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