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Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis

Research Project

Project/Area Number 20790140
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionUniversity of Shizuoka

Principal Investigator

HAYASHI Hideki  University of Shizuoka, 薬学部, 講師 (00419665)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords関節リウマチ / メトトレキサート / オーダーメード医療 / 遺伝薬理学 / TDM
Research Abstract

We evaluated the association of possible factors with the cumulative value of C-reactive protein in Japanese patients with RA. Polymorphisms of the reduced folate carrier gene (RFC) G80A and of the gamma-glutamylhydrolase gene (GGH) C-401T were more closely associated (beta = 2.1194, P = 0.0017) than other polymorphisms, with the anti-inflammatory response to MTX. Plasma homocysteine levels in patients with the MTHFR 677TT genotype were significantly higher than in those with the 677CC genotype (p < 0.05). In addition, plasma homocysteine levels were increased along with the elevation of general inflammatory markers.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009 2008

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (8 results)

  • [Journal Article] Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population2010

    • Author(s)
      Hayashi H, Horino M, Morishita M, Tazoe Y, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Tsuji D, Inoue K, Itoh K
    • Journal Title

      Drug Metab.Pharmacokinet. (in press)

    • NAID

      10027583938

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.2009

    • Author(s)
      Hayashi H, Fujimaki C, Daimon T, Tsuboi S, Matsuyama T, Itoh K
    • Journal Title

      J. Clin. Pharm. Ther. 34

      Pages: 355-361

    • Related Report
      2009 Final Research Report
  • [Journal Article] Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis2009

    • Author(s)
      Fujimaki C, Hayashi H, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Inoue K, Itoh K
    • Journal Title

      Biomarkers 14

      Pages: 49-54

    • Related Report
      2009 Final Research Report
  • [Journal Article] Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis.2009

    • Author(s)
      Hideki Hayashi, et al.
    • Journal Title

      Journal of Clinical Pharmacy and Therapeutics 34

      Pages: 355-361

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms in folate pathway enzymes as a possible marker for predicting the outcome of methotrexate therapy in Japanese patients with rheumatoid arthritis2009

    • Author(s)
      Hideki Hayashi, et.al.
    • Journal Title

      Journal of Clinical Pharmacy and Therapeutics (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma total homocysteine level and methylenetetrahydrofolate reductase 677C>T genetic polymorphism in Japanese patients with rheumatoid arthritis2009

    • Author(s)
      Chihiro Fujimaki, et.al.
    • Journal Title

      Biomarkers 14

      Pages: 49-54

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 関節リウマチにおけるmethotrexate反応性予測因子としてのdihydrofolate reductase2010

    • Author(s)
      堀野雅人、林秀樹, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山県桃太郎アリーナ
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおけるmethotrexate反応性予測因子としてのdihydrofolate reductase遺伝子多型2010

    • Author(s)
      堀野雅人, 林秀樹, 藤巻千裕, 森下茉莉子, 小菅和仁, 坪井声示, 松山耐至, 山田浩, 井上和幸, 辻大樹, 伊藤邦彦
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ患者におけるテーラーメイド薬物療法の実現を目指した遺伝子多型解析研究2009

    • Author(s)
      藤巻千裕, 林秀樹, 松山耐至, 坪井声示, 井上和幸, 伊藤邦彦
    • Organizer
      第23回静岡県病院薬剤師会学術大会
    • Place of Presentation
      静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ患者における赤血球中メトトレキサート活性体濃度測定2009

    • Author(s)
      林秀樹, 藤巻千裕, 松山耐至, 坪井声示, 井上和幸, 伊藤邦彦
    • Organizer
      第23回静岡県病院薬剤師会学術大会
    • Place of Presentation
      静岡
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ患者におけるメトトレキサートの薬効に影響する遺伝的因子2008

    • Author(s)
      林秀樹、他
    • Organizer
      第18回日本医療薬学会年会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2008-09-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ患者におけるメトトレキサートの薬効に影響する遺伝的因子2008

    • Author(s)
      林秀樹, 藤巻千裕, 坪井声示, 大門貴志, 松山耐至, 井上和幸, 伊藤邦彦
    • Organizer
      第18回日本医療薬学会年会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] 関節リウマチ患者における血球中メトトレキサート濃度測定2008

    • Author(s)
      林秀樹, 藤巻千裕, 坪井声示, 松山耐至, 井上和幸, 伊藤邦彦
    • Organizer
      第54回日本薬学会東海支部総会・大会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Final Research Report
  • [Presentation] ホモシステインと疾患活動性~関節リウマチにおける検討~ハイライト集収載2008

    • Author(s)
      林秀樹, 藤巻千裕, 坪井声示, 松山耐至, 原田直人, 伊藤邦彦
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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