Establishment of tailor-made drug therapy that aims at improvement of quality of life in patients with rheumatoid arthritis
Project/Area Number |
20790140
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | University of Shizuoka |
Principal Investigator |
HAYASHI Hideki University of Shizuoka, 薬学部, 講師 (00419665)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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Keywords | 関節リウマチ / メトトレキサート / オーダーメード医療 / 遺伝薬理学 / TDM |
Research Abstract |
We evaluated the association of possible factors with the cumulative value of C-reactive protein in Japanese patients with RA. Polymorphisms of the reduced folate carrier gene (RFC) G80A and of the gamma-glutamylhydrolase gene (GGH) C-401T were more closely associated (beta = 2.1194, P = 0.0017) than other polymorphisms, with the anti-inflammatory response to MTX. Plasma homocysteine levels in patients with the MTHFR 677TT genotype were significantly higher than in those with the 677CC genotype (p < 0.05). In addition, plasma homocysteine levels were increased along with the elevation of general inflammatory markers.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Dihydrofolate reductase gene intronic 19-bp deletion polymorphisms in a Japanese population2010
Author(s)
Hayashi H, Horino M, Morishita M, Tazoe Y, Tsuboi S, Matsuyama T, Kosuge K, Yamada H, Tsuji D, Inoue K, Itoh K
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Journal Title
Drug Metab.Pharmacokinet. (in press)
NAID
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[Presentation] 関節リウマチにおけるmethotrexate反応性予測因子としてのdihydrofolate reductase遺伝子多型2010
Author(s)
堀野雅人, 林秀樹, 藤巻千裕, 森下茉莉子, 小菅和仁, 坪井声示, 松山耐至, 山田浩, 井上和幸, 辻大樹, 伊藤邦彦
Organizer
日本薬学会第130年会
Place of Presentation
岡山
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