| Project/Area Number |
20790147
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
SUZUKI Toshihiro Meiji Pharmaceutical University, 薬学部, 講師 (80322527)
|
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | シスプラチン / miRNA / 薬剤耐性 / バイオマーカー / 肺癌 |
|---|
| Research Abstract |
Cisplatin is an effective anticancer agent that is widely used in the treatment of cancer. However, the development of resistance to cisplatin is a major obstacle to treatment. To understand the clinically relevant mechanisms of resistance, many studies have been aimed at clarifying the biochemical/molecular alterations of cisplatin-resistance cells. However, these studies did not conclusively identify the basis of cellular resistance to cisplatin.
In this study, micro RNA expression profiles of cisplatin resistant cell lines were analyzed using microarray and real time RT-PCR. We found some of micro RNAs were similarly regulated in couple of cisplatin resistant non small lung cancer cell lines. These finding were useful information for understanding of the miRNA mediated cisplatin resistance mechanisms.
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