| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Research Abstract |
Transporter play important role in the drug resistance of leukemia. In this study, novel quantitative method of transporter protein was developed with mass spectrometer. The expression levels of transporter proteins were elucidated in vincristine (VCR) resistant leukemia cells. VCR resistant leukemia cell was 67 times as ABCB1 expression level as VCR sensitive leukemia cells. Other transporters including ABCC family, which were known as vincristin transporters, did not show difference in expression level between resistant cells and sensitive cells. These results suggested important role of ABCB1 in vincristin resistance of leukemia cells.
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