Clarification of the mechanism of the hypersensitivity induced by the antineoplastic agent paclitaxel and identification of a prophylactic agent for this hypersensitivity
| Project/Area Number |
20790154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Medical pharmacy
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| Research Institution | Fukuyama University |
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Principal Investigator |
GOROMARU Takeshi Fukuyama University, 薬学部, 講師 (70412319)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 医薬品 / 副作用 / 過敏反応 / パクリタキセル |
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| Research Abstract |
Paclitaxel-induced hypersensitivity is thought to be caused by the solvent Cremophor EL. We studied the hypersensitivity responses in rats that received 3 paclitaxel formulations prepared using different solvents. The levels of hypersensitivity to the 3 formulations were not significantly different. These findings suggest that paclitaxel-induced hypersensitivity is caused not by the solvent, but by the active ingredient of the formulation. In addition, ibudilast was found to attenuate the paclitaxel-induced pulmonary vascular hyperpermeability. We found that ibudilast was useful for prophylaxis against paclitaxel-induced hypersensitivity.
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Report
(3 results)
Research Products
(7 results)
