| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
It has been reported that iAs^<III> administered intravenously is excreted into bile as arsenic-glutathione (As-GSH) complexes such as arsenic triglutathione (ATG) and methylarsenic diglutathione (MADG). Glutathione plays an important role in the metabolism of arsenic. MADG, but not ATG, was decomposed by γ-glutamyl transpeptidase (GGT). After biriary excretion ATG may be hydrolyze to toxic iAs^<III> rather than decomposed by GGT. The influence of GGT on an excretion of arsenic was investigated. As-GSH complexes were found in urine of rats treated with a GGT inhibitor, but not with saline (control group). These results suggest that concentration increasing of GSH caused by inhibition of GGT plays important role in the detoxification of arsenic.
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