| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Hepatic stellate cells (HSCs) are known to be a site of vitamin A storage and play an important role in liver fibrogenesis, as they are activated on liver injury to produce collagens. We have revealed that HSCs become retinoid responsive after activation through post-transcriptional up-regulation of retinoic acid receptor (RAR)α gene expression and that these RARα proteins showed a speckled distribution in the cytosol. We further analyzed these speckled RARα proteins and proposed that insoluble, cytosolic speckled distribution of RARα proteins in activated HSCs may represent a marker for HSC activation.
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