| Project/Area Number |
20790159
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
|
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| Research Institution | Gunma University |
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Principal Investigator |
SATO Mahito Gunma University, 大学院・医学系研究科, 助教 (60375532)
|
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | マクロファージ / 異物貪食 / 遺伝子欠失マウス / 小胞輸送 / 異物貪食機構 |
|---|
| Research Abstract |
Phagocytosis by macrophages plays important roles in immune response to microbes. In this study, we investigated the molecular mechanisms of phagocytosis by using mice lacking the VAMP7 gene, which regulate vesicular trafficking. The results show the possible roles of VAMP7 in phagocytosis and phagosome-lysosome fusion in macrophages through some specific pathways. However, we also revealed that VAMP7 does not regulate immune response to malaria. The physiological roles of VAMP7 are still to be investigated.
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