Reincorporation of cathepsin D in neurons of mouse brain.
Project/Area Number |
20790162
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
General anatomy (including Histology/Embryology)
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Research Institution | Niigata University |
Principal Investigator |
SHIBATA Masahiro Niigata University, 医歯学系, 准教授 (10343253)
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Project Period (FY) |
2008 – 2009
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Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | リソソーム / カテプシン / ライソゾーム病 / セロイドリポフスチノーシス / カテプシンD / トランスポゾン / ミクログリア / NCL |
Research Abstract |
Central nervous system specific cathepsin D (CD) deficient mice (CD:NesCre) ied around P40 by seizures and their phenotype was similar to neuronal ceroid lipofuscinosis. We noticed that CD protein was detected in neurons of CD:NesCre mice by immunohistochemistry, although CD mRNA was not expressed in the neurons. These results indicate that CD:NesCre neurons receive CD from other type of cells. We have also developed the chick experimental model to examine the transport system of lysosomal enzymes and established the stable expression system of transgenes into chick genome.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation2009
Author(s)
Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, Dono K, Doki Y, Kominami E, Sugioka A, Monden M
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Journal Title
Uchiyama Y. Autophagy 5(3)
Pages: 351-60
Related Report
Peer Reviewed
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