The analysis of molecular mechanism of Caudal Regression Syndrome (CRS)

Research Project

Project/Area Number	20790163
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General anatomy (including Histology/Embryology)
Research Institution	Kumamoto University
Principal Investigator	SUZUKI Kentaro Kumamoto University, 発生医学研究所 (20404345)
Project Period (FY)	2008 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	先天異常学 / 奇形学 / 尾部退行症候群(人魚病) / 増殖因子 / 尾部退行症候群 / 泌尿生殖器
Research Abstract	Caudal regression syndrome (CRS) comprises developmental anomalies of the caudal vertebrae, urogenital organs and hind limbs. The mermaid like phenotypes has been often described in many literatures including old legends. However, the pathogenetic mechanisms are not understood. This study suggested that Bmp4, one of the Bmp ligands, may be essential molecule to make the caudal body with regulating the expression of patterning genes.