| Project/Area Number |
20790165
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
FUJIWARA Ken Jichi Medical University, 医学部, 講師 (00382945)
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| Co-Investigator(Renkei-kenkyūsha) |
YASHIRO Takashi 自治医科大学, 医学部, 教授 (80119859)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 下垂体前葉 / レチノイン酸 / オートクライン / パラクライン / 細胞間相互作用 / 腫瘍 / 下垂体 / エストロゲン |
|---|
| Research Abstract |
The anterior pituitary gland secrets six types of hormones, which are crucial to maintain growth, reproduction, and homeostasis. The purpose of this study is to clarify the relationship between retinoic acid (RA) and tumorigenesis of pituitary. I demonstrated that RA synthesizing enzyme was reduced in estrogen-induced prolactinoma model rats, and that the effect was mediated by estrogen receptor alpha. In addition, RA exerted effects on several genes expression in the anterior pituitary cells. It is hoped that these results contribute to elucidating the neoplasia mechanism and tumor therapy.
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