| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Mammals and birds possess high-performance primary-urine producing apparatus(renal glomerulus) by virtue of their high blood pressure. However, the protection mechanisms of glomerular structure from the high intraglomerular pressure and fluid shear stress remain poorly understood. In this study, we found that primary cilium, which is one of the fluid mechanosensors, disappeared from the glomerular podocytes in mammalian and bird metanephros. The primary cilia on the podocytes are subjected to a stronger bending force in mammals and birds. Thus the disappearance of the primary cilia presumably prevents the entry of excessive calcium-ion via the cilium-associated calcium channels and the disturbance of intracellular signaling cascades in podocytes.
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