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Functional and molecular analysis of DSCR1 as a regulator of vascular morphology

Research Project

Project/Area Number 20790168
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionNippon Medical School

Principal Investigator

FUJIWARA Masakazu  Nippon Medical School, 老人病研究所, 助教 (20312069)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords発生学 / 形態形成学 / 血管新生 / 血管形成 / 血管内皮細胞
Research Abstract

Morphology of blood vessels is diverse. However, we do not know how these morphological variations are made during vasculogenesis/angiogenesis. In this study, we found that DSCR1 regulates the morphology of blood vessels by suppressing the branching of blood vessels during vasculogenesis/angiogenesis. In the near future, we may generate blood vessels with appropriate morphology for the patients by using DSCR1 as a new vasculogenesis/angiogenesis suppressor.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 3 results) Presentation (5 results)

  • [Journal Article] Dynamic and complex movement during formation of vascular structures studied with the fibrin bead assay2008

    • Author(s)
      Fujiwara Masakazu、Ghazizadeh Mohammad、Kawanami Oich
    • Journal Title

      J Nippon Med Sch 75巻

      Pages: 194-5

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of down syndrome critical region 1 represses vascular branching in Xenopus laevis larvae2008

    • Author(s)
      Fujiwara Masakazu
    • Journal Title

      J Nippon Med Sch 75巻

      Pages: 62-4

    • NAID

      130004057326

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic and complex cell movement during formation of vascular structures studied with the fibrin bead assay2008

    • Author(s)
      Fujiwara Masakazu
    • Journal Title

      J Nippon Med Sch 75

      Pages: 194-5

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of down syndrome critical region 1 represses vascular branching in Xenopus laevis larva2008

    • Author(s)
      Fujiwara Masakazu
    • Journal Title

      J Nippon Med Sch 75

      Pages: 62-4

    • NAID

      130004057326

    • Related Report
      2008 Annual Research Report
  • [Presentation] VEGFによって誘導される遺伝子の血管形態における役割2009

    • Author(s)
      藤原正和
    • Organizer
      第17回日本血管生物医学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Down syndrome critical region 1 represses vascular branching in Xenopus laevis larvae2008

    • Author(s)
      Fujiwara Masakazu
    • Organizer
      International Vascular Biology Meeting
    • Place of Presentation
      Sydney
    • Related Report
      2009 Final Research Report
  • [Presentation] Overexpression of regulator of calcineurin 1 represses vascular branching in Xenopus laevis larvae2008

    • Author(s)
      Fujiwara Masakazu
    • Organizer
      The 6th Korea-Japan Symposium on Vascular Biology
    • Place of Presentation
      Kanazawa, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Down Syndrome Critical Region 1 Represses Vascular Branching in Xenopus laevis Larvae2008

    • Author(s)
      Fujiwara Masakazu
    • Organizer
      International Vascular Biology Meeting
    • Place of Presentation
      Sydney
    • Related Report
      2008 Annual Research Report
  • [Presentation] Overexpression of Regulator of Calcineurin 1 Represses Vascular Branching in Xenopus laevis Larvae2008

    • Author(s)
      Fujiwara Masakazu
    • Organizer
      The 6th Korea-Japan Joint Symposium on Vascular Biology
    • Place of Presentation
      Kanazawa
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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