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Molecular mechanism of synapsis checkpoint in mammalian meiosis

Research Project

Project/Area Number 20790169
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionFujita Health University

Principal Investigator

KOGO Hiroshi  Fujita Health University, 総合医科学研究所, 助教 (20282387)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords減数分裂 / 不妊症 / 不育症 / チェックポイント / 対合 / ノックアウトマウス / 不妊 / リン酸化 / 無精子 / 流産 / チェックプイント / ノックアトマウス / 雌雄差
Research Abstract

Meiosis is a special type of cell division producing oocytes and sperms. The failure in the process of meiosis causes infertility and miscarriage in human reproduction. To avoid such problems, there is a surveillance mechanism called meiotic checkpoint, although its molecular mechanism has been totally unknown, especially in mammals. In this study, the function of a meiosis-specific gene HORMAD1 was analyzed by generating gene-targeted mice. As a result, HORMAD1 was identified as the first gene required for the meiotic checkpoint in mammals.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (25 results)

All 2010 2009 2008 Other

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (8 results) Remarks (3 results)

  • [Journal Article] Screening of genes involved in chromosome segregation during meiosis I: towards the identification of genes responsible for infertility in humans.2010

    • Author(s)
      Kogo, H., Kowa- Sugiyama, H., Yamada, K., Bolor, H., Tsutsumi, M., Ohye, T., Inagaki, H., Taniguchi, M., Toda, T., Kurahashi, H.
    • Journal Title

      J. Hum. Genet. 55(5)

      Pages: 293-299

    • NAID

      10030734983

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paternal origin of the de novo constitutional t(11;22)(q23;q11).2010

    • Author(s)
      Ohye, T., Inagaki, H., Kogo, H., Tsutsumi, M., Kato, T., Tong, M., Macville, M.V., Medne, L., Zackai, E.H., Emanuel, B.S. Kurahashi, H.
    • Journal Title

      Eur. J. Hum. Genet. (in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Screening of genes involved in chromosome segregation during meiosis I : towards the identification of genes responsible for infertility in humans2010

    • Author(s)
      Kogo, H.et al.
    • Journal Title

      Journal of Human Genetics (in press)

    • NAID

      10030734983

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paternal origin of the de novo constitutional t(11;22)(q23;q11)2010

    • Author(s)
      Ohye, T.et al.
    • Journal Title

      European Journal of Human Genetics (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutations of the SYCP3 gene in women with recurrent pregnancy loss.2009

    • Author(s)
      Bolor, H., Mori, T., Nishiyama, S., Ito, Y., Hosoba, E., Inagaki, H., Kogo, H., 他11名
    • Journal Title

      Am. J. Hum. Genet. 84

      Pages: 14-20

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability mediated by non-B DNA: Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans.2009

    • Author(s)
      Inagaki, H., Ohye, T., Kogo, H., Kato, T., Bolor, H., Taniguchi, M., Shaikh, T.H., Emanuel, B.S., Kurahashi, H.
    • Journal Title

      Genome Res. 19

      Pages: 191-198

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells.2009

    • Author(s)
      Kurahashi, H. Inagaki, H., Kato, T., Hosoba, E., Kogo, H., Ohye, T., Tsutsumi, M., Bolor, H., Tong, M., Emanuel, B.S.
    • Journal Title

      Hum. Mol. Genet. 18

      Pages: 3397-3406

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities.2009

    • Author(s)
      Kurahashi, H., Bolor, H., Kato, T., Kogo, H., Tsutsumi, M., Inagak i, H., Ohye, T.
    • Journal Title

      J Hum Genet. 54

      Pages: 253-260

    • NAID

      10030730167

    • Related Report
      2009 Final Research Report
  • [Journal Article] Impaired DNA replication prompts deletions within palindromic sequences, but does not induce translocations in human cells2009

    • Author(s)
      Kurahashi, H.et al.
    • Journal Title

      Human Molecular Genetics 18

      Pages: 3397-3406

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recent advance in our understanding of the molecular nature of chromosomal abnormalities2009

    • Author(s)
      Kurahashi, H.et al.
    • Journal Title

      Journal of Human Genetics 54

      Pages: 253-260

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Mutations of the SYCP3 gene in women with recurrent pregnancy loss2009

    • Author(s)
      Bolor, H.
    • Journal Title

      American Journal of Human Genetics 84

      Pages: 14-20

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of pregnancy-associated plasma protein-A2 in the serum of pre-eclamptic patients.2008

    • Author(s)
      Nishizawa, H., Pryor-Koishi, K., Suzuki, M., Kato, T., Kogo, H., Sekiya, T., Kurahashi, H., Udagawa, Y.
    • Journal Title

      Mol. Hum. Reprod. 14

      Pages: 595-602

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chromosomal instability mediated by non- B DNA : Cruciform conformation and not DNA sequence is responsible for recurrent translocation in humans2008

    • Author(s)
      Inagaki, H.
    • Journal Title

      Genome Research 19

      Pages: 191-198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Increased levels of pregnancy- associated plasma protein- A2 in the serum of pre- eclamptic patients2008

    • Author(s)
      Nishizawa, H.
    • Journal Title

      Molecular Human Reproduction 14

      Pages: 595-602

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] HORMAD1は哺乳類の減数分裂における対合チェックポイントに必須である.2010

    • Author(s)
      向後寛、堤真紀子、大江瑞恵、稲垣秀人、倉橋浩樹
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] HORMAD1は哺乳類の減数分裂における対合チェックポイントに必須である2010

    • Author(s)
      向後寛
    • Organizer
      第115回日本解剖学会全国学術集会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] HORMAD1は哺乳類雌の対合チェックポイントに必須である.2009

    • Author(s)
      向後寛、堤真紀子、大江瑞恵、稲垣秀人、倉橋浩樹
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] HORMAD1は哺乳類雌の対合チェックポイントに必須である2009

    • Author(s)
      向後寛
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] 哺乳類の減数分裂におけるHORMAD1の機能と減数分裂チェックポイントの性差.2009

    • Author(s)
      向後寛, ボロルハスバイラ, 堤真紀子, 大江瑞恵, 稲垣秀人, 倉橋浩樹
    • Organizer
      第114回日本解剖学会全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 哺乳類の減数分裂におけるHORMAD1の機能と減数分裂チェックポイントの性差2009

    • Author(s)
      向後寛
    • Organizer
      第114回日本解剖学会全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 哺乳類の減数分裂におけるHORMAD1の機能とチェックポイントの性的二型性.2008

    • Author(s)
      向後寛、ボロルハスバイラ、堤真紀子、大江瑞恵、稲垣秀人、倉橋浩樹
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 哺乳類の減数分裂におけるHORMAD1の機能とチェックポイントの性的二型性2008

    • Author(s)
      向後寛
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://info.fujita-hu.ac.jp/~genome/mg/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://info.fujita-hu.ac.jp/~genome/mg/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.fujita-hu.ac.jp/~rgenome/mg/

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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