The functional involvement of Rho family on bone formation.

• Project/Area Number: 20790171
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Hiroshima International University
• Principal Investigator: FUKUYAMA Ryo Hiroshima International University, 薬学部, 助教 (20389117)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 発生学 / 形態形成学 / 骨代謝 / 発生・分化 / 歯学 / 骨芽細胞 / 骨代謝学

Research Abstract

In this study, to examine the physiological role of Rac on bone formation, we generated transgenic (Tg) mice that overexpressed L61Rac, a constitutively active form of Rac, in osteoblast using pro-α1(I) collagen promoter and examined the characteristic of Tg mice. Tg mice showed osteopenia due to inhibition of osteoblast maturation.

Research Products

• [Presentation] Benzo[b]furan 誘導体MU314 の骨吸収抑制作用発現機構に関する検討 (2011)
  • Author(s): 福山亮
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 大阪
  • Year and Date: 2011-11-19
• [Presentation] Benzo[b]furan誘導体MU-314の骨吸収抑制作用発現機構に関する検討 (2010)
  • Author(s): 福山亮
  • Organizer: 第118回日本薬理学会近畿部会
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
  • Year and Date: 2010-11-19
• [Remarks] ホームページ等
  • URL: http://web.me.com/ph.hirokoku.u.ac.jp/Lab/Phar.html
• [Remarks]
  • URL: http://web.me.com/ph.hirokoku.u.ac.jp/Lab/Phar.html
• [Remarks]
  • URL: http://web.me.com/ph.hirokoku.u.ac.jp/Lab/Phar.html