The functional involvement of Rho family on bone formation.
| Project/Area Number |
20790171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Hiroshima International University |
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Principal Investigator |
FUKUYAMA Ryo Hiroshima International University, 薬学部, 助教 (20389117)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 発生学 / 形態形成学 / 骨代謝 / 発生・分化 / 歯学 / 骨芽細胞 / 骨代謝学 |
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| Research Abstract |
In this study, to examine the physiological role of Rac on bone formation, we generated transgenic (Tg) mice that overexpressed L61Rac, a constitutively active form of Rac, in osteoblast using pro-α1(I) collagen promoter and examined the characteristic of Tg mice. Tg mice showed osteopenia due to inhibition of osteoblast maturation.
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Report
(4 results)
Research Products
(5 results)
