Novel mechanisms of t-PA-dependent liver regeneration

• Project/Area Number: 20790182
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General physiology
• Research Institution: Kinki University
• Principal Investigator: KAWAO Naoyuki Kinki University, 医学部, 助教 (70388510)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: t-PA / 細胞内シグナル伝達 / 肝再生 / 細胞内シグナル / プラスミノゲン / シグナル伝達

Research Abstract

The roles of plasminogen activator (PA) /plasmin system in liver repair was examined. Then, the PA/plasmin system contributes to hepatocyte proliferation. In addition, plasminogen is essential for triggering a cascade of sequential repair responses after liver injury.

Research Products

• [Journal Article] Plasminogen is essential for granulation tissue formation during the recovery process after liver injury in mice. (2010)
  • Author(s): Kawao N, Nagai N, Ishida C, Okada K, Okumoto K, Suzuki Y, Umemura K, Ueshima S, Matsuo O
  • Journal Title: J Thromb Haemost (In press)
  • Peer Reviewed
• [Journal Article] Role of plasminogen in macrophage accumulation during liver repair. (2010)
  • Author(s): Kawao N, Nagai N, Okada K, Okumoto K, Ueshima S, Matsuo O
  • Journal Title: Thromb Res. (in press)
  • Peer Reviewed
• [Journal Article] Role of plasminogen in macrophage accumulation during liver repair (2010)
  • Author(s): Kawao N et al.
  • Journal Title: Thromb Res. (in press)
  • Peer Reviewed
• [Journal Article] Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes. (2008)
  • Author(s): Okada K, Ueshima S, Kawao N, Okamoto C, Matsuo K, Akao M, Seki T, Ariga T, Tanaka M, Matsuo O
  • Journal Title: Blood Coagul Fibrinolysis Vol.19 Pages: 503-11
  • Peer Reviewed
• [Journal Article] Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes (2008)
  • Author(s): Okada K
  • Journal Title: Blood Coagul Fibrinolysis 19 Pages: 503-511
  • Peer Reviewed
• [Presentation] 肝修復過程のマクロファージおよび好中球の集積におけるプラスミノゲンの寄与 (2010)
  • Author(s): 河尾直之
  • Organizer: 第83回日本薬理学会年会
  • Place of Presentation: 大阪
• [Presentation] 肝傷害後の炎症性細胞の集積におけるプラスミノゲンの役割 (2009)
  • Author(s): 河尾直之
  • Organizer: 第32回日本血栓止血学会学術集会
  • Place of Presentation: 福岡
• [Presentation] 肝傷害後の炎症性細胞の集積におけるプラスミノゲンの役割 (2009)
  • Author(s): 河尾直之
  • Organizer: 第32回日本血栓止血学会学術集会
  • Place of Presentation: 北九州国際会議場(福岡県)
• [Presentation] 光化学刺激血栓モデルによる局所的肝傷害後の修復過程におけるプラスミノゲンの役割 (2008)
  • Author(s): 河尾直之
  • Organizer: 第31回日本血栓止血学会学術集会
  • Place of Presentation: 大阪
• [Presentation] 光化学刺激血栓モデルによる局所的肝傷害後の修復過程におけるプラスミノーゲンの役割 (2008)
  • Author(s): 河尾直之
  • Organizer: 第31回日本血栓止血学会学術集会
  • Place of Presentation: 大阪