Involvement of concentration-sensitive sodium channel in alveolar fluid clearance

Research Project

Project/Area Number	20790183
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	General physiology
Research Institution	Kinki University
Principal Investigator	HAGIWARA Teruki Kinki University, 理工学部, 助教 (70411577)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords	炎症 / ナトリウムチャネル / 急性肺障害 / Lung fluid clearance / 生理学 / 肺
Research Abstract	Physiological roles of concentration-sensitive sodium channels (Na_C : c=concentration) expressed in mouse alveolar epithelial cells are not yet known. In this study, we investigated the role of Na_C in alveolar fluid clearance. Na_C expression dramatically decreased in the lung during inflammation induced by lipopolysaccharide. Lung fluid content increased during early inflammation and decreased after the recovery of Na_C expression. These results suggested that LPS-induced suppression of Na_C in alveolar epithelial cells reduced AFC and caused the increase in lung fluid content in acute lung injury.

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