Involvement of concentration-sensitive sodium channel in alveolar fluid clearance
| Project/Area Number |
20790183
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
HAGIWARA Teruki Kinki University, 理工学部, 助教 (70411577)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 炎症 / ナトリウムチャネル / 急性肺障害 / Lung fluid clearance / 生理学 / 肺 |
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| Research Abstract |
Physiological roles of concentration-sensitive sodium channels (Na_C : c=concentration) expressed in mouse alveolar epithelial cells are not yet known. In this study, we investigated the role of Na_C in alveolar fluid clearance. Na_C expression dramatically decreased in the lung during inflammation induced by lipopolysaccharide. Lung fluid content increased during early inflammation and decreased after the recovery of Na_C expression. These results suggested that LPS-induced suppression of Na_C in alveolar epithelial cells reduced AFC and caused the increase in lung fluid content in acute lung injury.
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Report
(4 results)
Research Products
(4 results)
