Analysis of coupling mechanism of voltage-gated H^+ channel and NADPH oxidase
| Project/Area Number |
20790189
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
General physiology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OKOCHI Yoshifumi Osaka University, 医学系研究科, 助教 (90435818)
|
|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 電位依存性プロトンチャネル / 好中球 / 活性酸素 / NADPHオキシダーゼ / 貪食細胞 |
|---|
| Research Abstract |
We found that voltage-gated proton channel, VSOP, regulates reactive oxygen species (ROS) generation in neutrophils, which have the ability of killing pathogens. We also found the possibility that VSOP and NADPH oxidase interact physically and that both molecules are present in same location of neutrophils. These results suggest that VSOP can regulate intracellular/extracellular proton and membrane potential properly by interaction with NADPH oxidase and then regulate ROS generation.
|
Report
(3 results)
Research Products
(15 results)
