Role of clock genes and feeding peptides on circadian thermoregulation

• Project/Area Number: 20790195
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Waseda University
• Principal Investigator: TOKIZAWA Ken Waseda University, 人間科学学術院, 助手 (00454083)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 温熱生理学 / 生体リズム / 生物時計 / 摂食調節 / 自律神経調節

Research Abstract

The circadian rhythm of body temperature is a well-known phenomenon. However, it is unknown how the circadian system including the suprachiasmatic nucleus and clock genes affects thermoregulation. This study demonstrated that the circadian system per se is influenced by both the feeding condition and environmental temperature and that it modulates thermoregulation.

Research Products

• [Journal Article] Thermoregulation in the cold changes depending on the time of day and feeding condition: physiological and anatomical analyses of involved circadian mechanisms. (2009)
  • Author(s): Tokizawa K, Uchida Y, Nagashima K.
  • Journal Title: Neuroscience Vol.164No.3 Pages: 1377-86
  • Peer Reviewed
• [Journal Article] Thermoregulation in the cold changes depending on the time of day and feeding condition : physiological and anatomical analyses of involved circadian mechanisms (2009)
  • Author(s): Tokizawa K, Uchida Y, Nagashima K
  • Journal Title: Neuroscience 164 Pages: 1377-1386
  • Peer Reviewed
• [Presentation] CLOCK GENE PLAYS AN IMPORTANT ROLE IN CIRCADIAN CHANGES IN THERMOREGULATION DURING FASTING IN MICE (2009)
  • Author(s): Ken Tokizawa, Yuki Uchida, Kei Nagashima
  • Organizer: Third International Symposium on Physiology and Pharmacology of Temperature Regulation
  • Place of Presentation: 松江
  • Year and Date: 2009-07-23
• [Presentation] Clock gene plays an important role in time-dependent change in thermoregulation during cold exposure in fasted mice (2009)
  • Author(s): Ken Tokizawa, Yuki Uchida, Kei Nagashima
  • Organizer: Experimantal Biology 2009
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-04-18
• [Presentation] レプチンおよびグレリンが絶食時の時間特異的体温調節反応に及ぼす影響 (2009)
  • Author(s): 時澤健、尾上侑己、内田有希、森久恵、中村真由美、永島計
  • Organizer: 日本時間生物学会
  • Place of Presentation: 大阪
• [Presentation] レプチンが寒冷時体温調節反応および絶食時日内休眠に及ぼす影響 (2009)
  • Author(s): 時澤健、永島計
  • Organizer: 日本体力医学会
  • Place of Presentation: 新潟
• [Presentation] Time-dependent changes in thermoregulation during cold exposure in fasted mice (2009)
  • Author(s): K Tokizawa, Y Uchida, K Nagashima
  • Organizer: International Union of Physiological Sciences
  • Place of Presentation: 京都
• [Presentation] CLOCK GENE PLAYS AN IMPORTANT ROLE IN CIRCADIAN CHANGES IN THERMOREGULATION DURING FASTING IN MICE (2009)
  • Author(s): K Tokizawa, Y Uchida, K Nagashima
  • Organizer: International Symposium on Physiology and Pharmacology of Temperature Regulation
  • Place of Presentation: 島根
• [Presentation] Clock gene plays an important role in time-dependent change in thermoregulation during cold exposure in fasted mice (2009)
  • Author(s): K Tokizawa, Y Uchida, K Nagashima
  • Organizer: Experimental Biology 2009
  • Place of Presentation: ニューオリンズ、アメリカ
• [Presentation] 絶食時の体温概日リズム調節機構の解明 (2008)
  • Author(s): 時澤健、内田有希、永島計
  • Organizer: 日本時間生物学会
  • Place of Presentation: 岡山大学
  • Year and Date: 2008-11-08
• [Presentation] Fasting affects thermoregulation and hypothalamic Fos expressions in the cold, depending on time of the day (2008)
  • Author(s): 時澤健、内田有希、永島計
  • Organizer: 日本神経科学会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2008-07-09
• [Presentation] 絶食時の体温概日リズム調節機構の解明 (2008)
  • Author(s): 時澤健、内田有希、永島計
  • Organizer: 日本時間生物学会
  • Place of Presentation: 岡山
• [Presentation] Fasting affects thermoregulation and hypothalamic Fos expressions in the cold, depending on time of the day (2008)
  • Author(s): K Tokizawa, Y Uchida, K Nagashima
  • Organizer: 日本神経科学会
  • Place of Presentation: 東京