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Analysis of circadian clock system by mouse mutagenesis for light inducible and circadian expressed genes.

Research Project

Project/Area Number 20790196
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

FUKUMURA Ryutaro  The Institute of Physical and Chemical Research, 新規変異マウス研究開発チーム, 開発研究員 (90392240)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords概日リズム / マウスENUミュータジェネシス / 変異マウス
Research Abstract

We obtained 7 mutants for Snk, Slc39a6 and Dusp4 genes, which are induced by light and oscillated with a circadian rhythm, by RIKEN ENU-based gene-driven mutagenesis system. Snk and Slc39a6 mutant mice were normal with respect to the circadian rhythm by constant dark condition. Therefore, we could not indicate that these mutations are related to a circadian clock system. We however found that the Slc39a6 mutant male mice were infertile. It is a new finding that the Slc39a6 gene is related to the male sterility.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (13 results)

All 2009 2008 Other

All Journal Article (6 results) (of which Peer Reviewed: 2 results) Presentation (5 results) Book (2 results)

  • [Journal Article] Next-generation gene targeting in the mouse for functional genomics2009

    • Author(s)
      Gondo Y, Fukumura R(4名中2番目)
    • Journal Title

      BMM Rep 42

      Pages: 315-323

    • Related Report
      2009 Final Research Report
  • [Journal Article] Serine racemase is associated with schizophrenia susceptibility in human and in a mouse model.2009

    • Author(s)
      Labrie V, Fukumura R(15名中2番目)
    • Journal Title

      Hum Mol Genet 18

      Pages: 3227-3243

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] ENU-induced mutant mice for a next-generation gene-targeting system.2009

    • Author(s)
      Gondo Y, Fukumura R
    • Journal Title

      progress in Brain Research 179

      Pages: 29-34

    • Related Report
      2009 Final Research Report
  • [Journal Article] Next-generation gene targeting in the mouse for functional genomics2009

    • Author(s)
      Gondo Y
    • Journal Title

      BMM Rep 42

      Pages: 315-323

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Serine racemase is associated with schizophrenia susceptibility in human and in a mouse model2009

    • Author(s)
      Labrie V
    • Journal Title

      Hum Mol Genet. 18

      Pages: 3227-3243

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ENU-induced mutant mice for a next-generation gene-targeting system2009

    • Author(s)
      Gondo Y
    • Journal Title

      Progress in Brain Research 179

      Pages: 29-34

    • Related Report
      2009 Annual Research Report
  • [Presentation] Next-generation gene targeting system based on ENU mutagenesis2009

    • Author(s)
      Fukumura R
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      日本横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Next-generation gene targeting system based on ENU mutagenesis2009

    • Author(s)
      福村龍太郎
    • Organizer
      第32回 日本分子生物学会年会
    • Place of Presentation
      日本 横浜
    • Year and Date
      2009-12-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evaluation of a massive mutations discovery method by exon enrichement system.2009

    • Author(s)
      Fukumura R
    • Organizer
      International Mammalian Genome Conference
    • Place of Presentation
      アメリカ、サンディエゴ
    • Year and Date
      2009-11-03
    • Related Report
      2009 Final Research Report
  • [Presentation] Evaluation of a massive mutations discovery method by exon enrichement system2009

    • Author(s)
      福村龍太郎
    • Organizer
      International mammalian genome conference
    • Place of Presentation
      アメリカCA La Jolla
    • Year and Date
      2009-11-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] 点突然変異検出法の比較とENU変異マウススクリーニングへの応用2008

    • Author(s)
      福村龍太郎
    • Organizer
      第31回日本分子生物学会年会
    • Place of Presentation
      神戸・国際展示場
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Book] モデル動物利用マニュアル

    • Author(s)
      福村龍太郎
    • Publisher
      ENUマウスミュータジェネシス(印刷中)
    • Related Report
      2009 Final Research Report
  • [Book] 「モデル動物利用マニュアル」:ENUマウスミュータジェネシス

    • Author(s)
      福村龍太郎
    • Publisher
      エル・アイ・シー(In press)
    • Related Report
      2009 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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