| Project/Area Number |
20790202
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKUBO Yohei The University of Tokyo, 大学院・医学系研究科, 助教 (40422282)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 中枢・末梢神経 / 脳・神経 / プルキンエ細胞 / バーグマングリア / カルシウ / IP3 / カルシウム |
|---|
| Research Abstract |
Synapse is a connecting point between neurons. The maintenance of synaptic functions is essential for stable neuronal information processing in the adult brain. Bergmann glial cells express glutamate transporters that rapidly remove glutamate from the extracellular space, and play a critical role in the precise operation of synaptic transmission in the cerebellum. We found that a signaling cascade comprising inositol 1,4,5-trisphosphate is involved in glutamate transporter expression to maintain the capacity of glutamate clearance. Thus, inositol 1,4,5-trisphosphate is essential for the maintenance of synaptic function.
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