Regulation of dopaminergic neuron development by trophic factor and neurofunction disorder

• Project/Area Number: 20790203
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General pharmacology
• Research Institution: Niigata University
• Principal Investigator: MIZUNO Makoto Niigata University, 超域研究機構, 准教授 (20345515)
• Project Period (FY): 2008 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
• Keywords: 栄養因子 / ドパミン / 認知 / 情動

Research Abstract

Neonatal administration of EGF perturbs dopaminergic development or function and induces schizophrenia-related abnormalities in cognitive and behavioral traits in adult stage. EGF treated rat was established as the model for schizophrenia.

Research Products

• [Journal Article] The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia (2008)
  • Author(s): Mizuno M, Kawamura H, Takei N, Nawa H
  • Journal Title: J Neural Transm 115 Pages: 521-530
  • Peer Reviewed
• [Journal Article] Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonates (2008)
  • Author(s): Tsuda N, Mizuno M, Yamanaka T, Komurasaki T, Yoshimoto M, Nawa H
  • Journal Title: Brain Dev 30 Pages: 533-543
  • NAID: 10025577732
  • Peer Reviewed
• [Presentation] Function of EGF receptor signaling in the neonatal hippocampal lesion model of schizophrenia (2009)
  • Author(s): 水野誠
  • Organizer: 第39回北米神経科学会
  • Place of Presentation: シカゴ、アメリカ合衆国
• [Presentation] Function of EGF receptor signaling in the neonatal hippocampal lesion model of schizophrenia (2009)
  • Author(s): 水野誠
  • Organizer: 第52回本神経化学会大会
  • Place of Presentation: 群馬県
• [Presentation] Effects of emodin for behavioral impairment in models of schizophrenia (2008)
  • Author(s): 水野誠
  • Organizer: ニューロサイエンス2008
  • Place of Presentation: ワシントンDC
  • Year and Date: 2008-11-19
• [Presentation] Effects of tyrosine kinase inhibitors on behavioral experiments in the neonatal hippocampal lesion model of schizophrenia (2008)
  • Author(s): 水野誠、鄭英君、外山英和、那波宏之
  • Organizer: 第38回北米神経科学会
  • Place of Presentation: ワシントンDC、アメリカ合衆国
• [Presentation] Antipsychotic effects of ErbB1 tyrosine kinase inhibitors on behavioral deficits in the neonatal hippocampal lesion model of schizophrenia (2008)
  • Author(s): 水野誠、鄭英君、川村宏樹、那波宏之
  • Organizer: 第51回日本神経化学会大会
  • Place of Presentation: 富山県