| Project/Area Number |
20790204
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
SUZUKI Yasuhiro Hamamatsu University School of Medicine, 医学部, 助教 (00324343)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Nobuo 長浜バイオ大, バイオサイエンス学部, 教授 (90260281)
YAMAKAWA Kasumi 浜松医科大学, 医学部附属病院, その他 (70563287)
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| Research Collaborator |
COLLEN Desire ルーヴァン大学, 分子血管生物学研究所, 前所長
LIJNEN Roger ルーヴァン大学, 分子血管生物学研究所, 所長
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 脳虚血 / 脳内出血 / 組織型プラスミノーゲン活性化因子 / 脳梗塞 |
|---|
| Research Abstract |
The delayed treatment with tissue-type plasminogen activor (t-PA) on ischemic stroke increases the risk of intracranial bleeding. When we can avoid it, we can save more patients by extending the therapeutic time window. We have found that low density lipoprotein receptor-related protein-1 (LRP-1) is upregulated in endothelial cells by ischemic stress, and the delayed-treated t-PA binds to LRP-1 and induces stromelysin-1 (MMP-3) through the nuclear factor kappa-B (NF-κB) activation. These findings suggest essential pathway for the cerebralvascular disorder by t-PA
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