Development of mathematical model of a Human atrial myocyte to evaluate new antiarrhythmic drugs for atrial fibrillation
| Project/Area Number |
20790206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Osaka University |
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Principal Investigator |
MURAKAMI Shingo Osaka University, 医学系研究科, 助教 (40437314)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 心臓 / 不整脈 / 抗不整脈 / 心房細動 / シミュレーション / 抗不整脈薬 |
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| Research Abstract |
In this study, I have developed a mathematical model of a Human atrial myocyte. Since characteristics of atrial myocyte differ among animals, the developed model allows us to evaluate effects of antiarrhythmic drug specifically for human. Although human atrial myocytes are difficult to obtain for experiments, by using the developed model, we can examine effects of virtual drug profiles in human atrial myocytes. The developed model may improve efficiency of drug development.
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Report
(3 results)
Research Products
(29 results)
