Role of cation transporter in the regulation of macrophage function.
| Project/Area Number |
20790215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
|---|
Principal Investigator |
IYODA Takuya Fukuoka University, 医学部, 助教 (80465715)
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|---|
| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルドステロン / 心障害 / 炎症・免疫 / トランスポーター / カルシウム |
|---|
| Research Abstract |
Recent studies have indicated the utility of mineralocorticoid receptor antagonist in cardiovascular injuries. Actually, chronic treatment with aldosterone can induce several pathological features, including cardiac hypertrophy, in experimental animals. In this study, we showed that NCX1 would be implicated in the progression of aldosterone-induced cardiac remodeling in experimental model of hyper-aldosteronism. These results suggest that NCX1 inhibitors might be useful for heart failure therapeutically.
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Report
(3 results)
Research Products
(54 results)
