Regulation of stem cell proliferation by Tsc-22
| Project/Area Number |
20790220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SUZUKI Hiroyuki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (70375509)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Tsc-22 / c-Myc / Oct4 / Eras / 幹細胞 / 転写因子 / 癌 / p21 / Oct-4 / ERas |
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| Research Abstract |
Tsc-22 inhibits ES cell proliferation with maintaining the pluripotency. By analyzing the transcriptional factors that interact with Tsc-22 among Yamanaka factors (Oct4, c-Myc, Klf4 and Sox2), we found that Tsc-22 interacts c-Myc and Oct4. Tsc-22 suppresses the c-Myc/Oct4-mediated inhibition of p21 promoters. Furthermore, Tsc-22 interacts with ERas and inhibits PI3 kinase-Akt pathway.
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Report
(3 results)
Research Products
(21 results)
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[Journal Article] Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals.2008
Author(s)
Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T
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Journal Title
Mod Rheumatol 18
Pages: 472-479
NAID
Related Report
Peer Reviewed
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[Journal Article] Tristetraprolin (TTP) gene polymorphisms in patients with rheumatoid arthritis and healthy individuals2008
Author(s)
Suzuki T, Tsutsumi A, Suzuki H, Suzuki E, Sugihara M, Muraki Y, Hayashi T, Chino Y, Goto D, Matsumoto I, Ito S, Miyazawa K, Sumida T
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Journal Title
Mod Rheumatol 18
Pages: 472-479
NAID
Related Report
Peer Reviewed
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