| Project/Area Number |
20790220
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SUZUKI Hiroyuki University of Tsukuba, 大学院・人間総合科学研究科, 助教 (70375509)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | Tsc-22 / c-Myc / Oct4 / Eras / 幹細胞 / 転写因子 / 癌 / p21 / Oct-4 / ERas |
|---|
| Research Abstract |
Tsc-22 inhibits ES cell proliferation with maintaining the pluripotency. By analyzing the transcriptional factors that interact with Tsc-22 among Yamanaka factors (Oct4, c-Myc, Klf4 and Sox2), we found that Tsc-22 interacts c-Myc and Oct4. Tsc-22 suppresses the c-Myc/Oct4-mediated inhibition of p21 promoters. Furthermore, Tsc-22 interacts with ERas and inhibits PI3 kinase-Akt pathway.
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