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Characterization of the cellular oxygen sensing machinery

Research Project

Project/Area Number 20790223
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General medical chemistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKAYAMA Koh  Tokyo Medical and Dental University, 難治疾患研究所, 特任講師 (10451923)

Project Period (FY) 2008 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords生体分子医学 / 低酸素応答 / 細胞死 / エネルギー代謝 / タンパク質複合体 / プロリン水酸化酵素 / PHD3 / PRP19 / タンパク質間相互作用 / プロリン水酸化 / タンパク質 / シグナル伝達 / プロテオーム / 免疫沈降 / 細胞培養 / 質量分析
Research Abstract

Organisms respond to hypoxia condition by regulating respiration and metabolism to maintain homeostasis. It is not clear yet what is the 'oxygen sensor' molecule in vivo. In the present study, we have characterized the hypoxia complex which is formed by prolyl-hydroxylase PHD3. As a result, we identified several different molecules which would play roles in oxygen sensing. PDH regulated the metabolism, while PRP19 suppressed the cell death in hypoxia treated cells.

Report

(3 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • Research Products

    (10 results)

All 2010 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (6 results)

  • [Journal Article] Cellular signal transduction of the hypoxia response.2009

    • Author(s)
      Nakayama K
    • Journal Title

      J. Biochem 146

      Pages: 757-765

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] The ubiquitin ligase Siah2 and the hypoxia response.2009

    • Author(s)
      Nakayama K., Qi J., Ronai Z.
    • Journal Title

      Mol. Cancer Res. 7

      Pages: 443-451

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular signal transduction of the hypoxia response2009

    • Author(s)
      Koh Nakayama
    • Journal Title

      J.Biochem. 146

      Pages: 757-765

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ubiquitin ligase Siah2 and the hypoxia response2009

    • Author(s)
      Koh Nakayama et.al., (他2名)
    • Journal Title

      Molecular Cancer Research (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010

    • Author(s)
      Koh Nakayama, (他2名)
    • Organizer
      Keystone Symposia:Hypoxia
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2010-01-21
    • Related Report
      2009 Final Research Report
  • [Presentation] Prolyl-hydroxylase PHD3 promotes the PRP19 intramolecular interaction and alters PRP19 activity during hypoxia response2010

    • Author(s)
      中山恒, 他2名
    • Organizer
      Keystone Symposia : Hypoxia
    • Place of Presentation
      Keystone, CO, USA
    • Year and Date
      2010-01-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009

    • Author(s)
      中山恒, (他2名)
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] Molecular mechanism of ubiquitin ligase PRP19 activation by prolyl-hydroxylase PHD3 during hypoxia response2009

    • Author(s)
      中山恒, 他2名
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008

    • Author(s)
      中山恒
    • Organizer
      BMB2008学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-11
    • Related Report
      2009 Final Research Report
  • [Presentation] HIFプロリン水酸化酵素PHD3によるエネルギー代謝調節機構2008

    • Author(s)
      中山恒
    • Organizer
      BMB2008
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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