The analysis for mechanisms of colon tumor suppression by Bcl11b

• Project/Area Number: 20790224
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Niigata University
• Principal Investigator: KATSURAGI Yoshinori Niigata University, 医歯学系, 助教 (60401759)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大腸がん / がん抑制遺伝子 / APC / Bcl11b / マウス

Research Abstract

We showed that Bcl11b is the novel colon tumor suppressor gene in mice and human, and Bcl11b is strongly expressed in ISCs and TA cells. Analyses of Bcl11b mutants and γ-irradiation experiments suggest that Bcl11b play roles in suppression of oversupply of TA cells.

Research Products

• [Journal Article] Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. (2010)
  • Author(s): Yamamoto T, Morita S, Go R, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
  • Journal Title: Int J Radiat Oncol Biol Phys. 77 Pages: 235-243
  • Peer Reviewed
• [Journal Article] Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice. (2010)
  • Author(s): Go R, Hirose S, Morita S, Yamamoto T, Katsuragi Y, Mishima Y, Kominami R.
  • Journal Title: Cancer Sci. 101 Pages: 1347-1353
  • Peer Reviewed
• [Journal Article] Clonally expanding thymocytes having lineage capability in gamma-ray-induced mouse atrophic thymus. (2010)
  • Author(s): Yamamoto T, Morita S, Go R, Obata M, Katsuragi Y, Fujita Y, Maeda Y, Yokoyama M, Aoyagi Y, Ichikawa H, Mishima Y, Kominami R.
  • Journal Title: Int J Radiat Oncol Biol Phys. Volume: 77(1) Pages: 235-243
  • Peer Reviewed
• [Journal Article] Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice. (2010)
  • Author(s): Go R, Hirose S, Morita S, Yamamoto T, Katsuragi Y, Mishima Y, Kominami R.
  • Journal Title: Cancer Sci. Volume: 101(6) Pages: 1347-53
  • Peer Reviewed
• [Journal Article] CLONALLY EXPANDING THYMOCYTES HAVING LINEAGE CAP ABILITY IN γ-RAY INDUCED MOUSE ATROPHIC THYMUS. (2010)
  • Author(s): T.Yamamoto, S.Morita, R.Go, M.Obata, Y.Katsuragi, Y.Fujita, Y.Maeda, M.Yokoyama, Y.Aoyagi, H.Ichikawa, Y.Mishima, R.Kominami
  • Journal Title: Int.J.Radiation Oncology Biol.Phys. 77(1) Pages: 235-243
  • Peer Reviewed
• [Journal Article] Bcl11b heterozygous genotype promotes clonal expansion and differen tiation arrest of thymocytes in γ-irradiated mice accompanying increased β-catenin expression. (2010)
  • Author(s): R.Go, S.Hirose, S.Morita, T.Yamamoto, Y.Katsuragi, Y.Mishima, R.Kominami.
  • Journal Title: Cancer Science Epub ahead of print(In press)
  • Peer Reviewed
• [Presentation] 木南凌Bcl11b は腸上皮細胞の恒常性を制御する大腸がん抑制遺伝子である (2010)
  • Author(s): 葛城美徳、坂牧僚、小幡美貴、三嶋行雄、権藤洋一
  • Organizer: 第33回日本分子生物学会(BMB2010)
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-08
• [Presentation] Bcl11bは腸上皮細胞の恒常性を制御する大腸がん抑制遺伝子である (2010)
  • Author(s): 葛城美徳、坂牧僚、小幡美貴、三嶋行雄、権藤洋一、木南凌
  • Organizer: 第33回日本分子生物学会(BMB2010)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-08
• [Presentation] 木南凌Bcl11b/Rit1 は正常な歯胚発生に必要である (2009)
  • Author(s): 葛城美徳, 安楽純子, 依田浩子, 大島勇人, 権藤洋一
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] Bcl11b/Rit1は正常な歯胚発生に必要である (2009)
  • Author(s): 葛城美徳, 安楽純子, 依田浩子, 大島勇人, 権藤洋一, 木南凌
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-12
• [Presentation] 木南凌放射線照射による萎縮胸腺内の前がん細胞の特徴と発がん機構 (2009)
  • Author(s): 葛城美徳, 郷梨江香, 森田慎一, 小幡美貴
  • Organizer: 日本放射線影響学会第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] γ線照射によるマウス萎縮胸腺内の前リンパ腫細胞形成には細胞増殖と分化停止が必要である (2009)
  • Author(s): 葛城美徳, 郷梨江香, 森田慎一, 小幡美貴, 木南凌
  • Organizer: 日本放射線影響学会 第52回大会
  • Place of Presentation: 広島
  • Year and Date: 2009-11-11
• [Presentation] 木南凌Bcl11b/Rit1 はハプロ不全な腸管がん抑制遺伝子として機能する (2009)
  • Author(s): 葛城美徳, 坂牧僚, 岩崎友洋, 佐藤俊大, 三嶋行雄, 落合雅子, 中釜斉, 権藤洋一,味岡洋一
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Bcl11b/Rit1はハプロ不全な腸管がん抑制遺伝子として機能する (2009)
  • Author(s): 葛城美徳, 坂牧僚, 岩崎友洋, 佐藤俊大, 三嶋行雄, 落合雅子, 中釜斉, 権藤洋一, 味岡洋一, 木南凌
  • Organizer: 第67回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Bcl11b はAPCMin/+マウスの消化管発がんを抑制するBMB2008 (2008)
  • Author(s): 葛城美徳
  • Organizer: 第31回日本分子生物学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Bcl11bはAPC^(Min/+)マウスの消化管発がんを抑制する (2008)
  • Author(s): 葛城美徳
  • Organizer: BM92008(第31回日本分子生物学会年会)
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2008-12-09
• [Book] ペコリーノがんの分子生物学 (2010)
  • Author(s): Lauren Pecorino (監訳)日合弘、木南凌(訳者)葛城美徳, ほか5名
  • Total Pages: 300
  • Publisher: メディカル・サイエンス・インターナショナル
• [Book] ペコリーノがんの分子生物学 (2010)
  • Author(s): Lauren Pecorino(監訳)日合弘、木南凌(訳者)葛城美徳, ほか5名
  • Total Pages: 300
  • Publisher: メディカル・サイエンス・インターナショナル
• [Remarks] ホームページ等