Study of the mechanism by which phospholipase C・ regulates proinflammatory cytokine production
| Project/Area Number |
20790229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
EDAMATSU Hironori Kobe University, 大学院・医学研究科, 助教 (70335438)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | シグナル伝達 / 免疫 / アレルギー / 炎症 / モデル動物 / 皮膚炎 / 癌 / サイトカイン / 慢性炎症 / 尋常性乾癬 / 疾患モデル動物 / 樹状細胞 / T細胞 / ホスホリパーゼ |
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| Research Abstract |
Phospholipase C・ (PLC・), an intracellular signaling molecule, was implicated in inflammation and tumorigenesis by our study of an experimental skin carcinogenesis model. The aim of this research was to investigate the mechanism of inflammatory reactions mediated by PLC・. This study showed that PLC・ plays an important role in regulation of cytokine production by non-immune cells, such as epidermal keratinocytes and dermal fibroblasts, thereby augmenting inflammation. In addition, keratinocyte-restricted overproduction of PLC・ in mice results in the development of dermatitis accompanied by the characteristic features seen in human psoriasis, such as helper T cell infiltration and the development of silvery adherent scales.
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Report
(3 results)
Research Products
(19 results)
