Fabrication and Transplantation of Common Marmoset ES cells-derived cardiomyocyte-sheets

• Project/Area Number: 20790236
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: General medical chemistry
• Research Institution: Keio University
• Principal Investigator: HATTORI Fumiyuki Keio University, 医学部, 研究員 (50398624)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 霊長類 / マーモセット / 心筋細胞 / 細胞シート / 移植 / 心臓再生 / 胚性幹細胞 / 再生医療 / Common Marmoset / Cardiomyocytes / embryonic stem cell / differentiation / characterization / growth / gene expression

Research Abstract

We showed that marmoset ES cells could differentiate into cardiomyocytes, and fabricated cardiomyocyte-sheet, transplanted it on a heart, and observed well-survived cardiomyocyte after four weeks.

Research Products

• [Journal Article] Strategies for ensuring that regenerative cardiomyocytes function properly and in cooperation with the host myocardium. (2010)
  • Author(s): Hattori F, Fukuda K.
  • Journal Title: Exp Mol Med. 42(3) Pages: 155-165
  • Peer Reviewed
• [Journal Article] Strategies for ensuring that regenerative cardiomyocytes function properly and in cooperation with the host myocardium. (2010)
  • Author(s): 服部文幸、福田恵一
  • Journal Title: Experimental Molecular Medicine Volume: 42 Pages: 155-165
  • Peer Reviewed
• [Journal Article] Common marmoset embryonic stem cell can differentiate into cardiomyocytes. (2008)
  • Author(s): Chen H, Hattori F, Murata M, Li W, Yuasa S, Onizuka T, Shimoji K, Ohno Y, Sasaki E, Kimura K, Hakuno D, Sano M, Makino S, Ogawa S, Fukuda K.
  • Journal Title: Biochem Biophys Res Commun. 369(3) Pages: 801-806
  • Peer Reviewed
• [Journal Article] Common marmoset embryonic stem cell can differentiate into cardiomyocytes (2008)
  • Author(s): Chen H, Hattori F, Murata M, Li W, Yuasa S, Onizuka T, Shimoji K, Ohno Y, Sasaki E, Kimura K, Hakuno D, Sano M, Makino S, Ogawa S, Fukuda K.
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 801-801
  • Peer Reviewed
• [Presentation] 心臓再生医療の実現を目指した、心筋細胞精製および効率的移植方法の開発 (2010)
  • Author(s): 服部文幸
  • Organizer: 第55回未来医療センターセミナー
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-07-20
• [Presentation] 非遺伝子改変心筋細胞精製方法および移植方法 (2010)
  • Author(s): 服部文幸
  • Organizer: 日本再生医学会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2010-03-18