| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
Sarcopenia is the loss of skeletal muscle mass and strength with age. The causes of sarcopenia are probably manifold and still remain to be completely elucidated. Satellite cells are muscle-specific stem cells and are responsible for the postnatal muscle maintenance, growth and regeneration. We previously showed that the number of satellite cells remarkably decreased with age. It is thought that a decrease in number of satellite cells causes decline of muscle regenerative potential and muscle mass. In this study, we identified a gene that decreased in the expression level in satellite cells with age and might relate to the maintenance of satellite cells, and examined the functions. This study results might lead to the development of preventive methods of sarcopenia.
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