| Project/Area Number |
20790249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SATO Atsushi Tokyo Medical and Dental University, 難治疾患研究所, 特任助教 (30451925)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | WNK / 偽性低アルドステイン症 / ショウジョウバエ(モデル生物) / 偽性低アルドステイン症2型 / モデル生物(ショウジョウバエ) / 偽性低アルドステン症2型 |
|---|
| Research Abstract |
WNK1 and WNK4 have been linked to a hereditary form of human hypertension known as Pseudohypoaldosteronism type II (PHAII). We identified that the malfunction of this regulation caused PHAII in mouse. However, this misregulation cannot cause all of pathological conditions of PHAII, such as a mental retardation, dental abnormalities and impaired growth. We started to look for the other interacting factor(s) of WNK using Drosophila melanogaster, and found the transcription factor, which worked at the downstream of WNK.
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