Joint disease and clock genes
| Project/Area Number |
20790250
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
TAKARADA Takeshi Kanazawa University, 薬学系, 助教 (30377428)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 時計遺伝子 / 軟骨細胞 / 骨関節組織 / indian hedgehog / Indian hedgehog / Bmall / Bmal1 / Per1 |
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| Research Abstract |
We have investigated the possible role of clock genes in mechanism underlying the regulation of chondrogenic differentiation processes. The results suggested that chondrogenic differentiation may be modulated by clock genes expressed by chondrocytes in association with the inhibition by Per1 of Bmal1/Clock-dependent indian hedgehog expression.
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Report
(3 results)
Research Products
(83 results)
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[Journal Article] Possible protection by notoginsenoside R1 against neurotoxicity of N-methyl-D-aspartate receptor composed of an NR1/NR2B heteromeric assembly.2009
Author(s)
Bin Gu*, Noritaka Nakamichi*, Wen-Sheng Zhang, Yukary Nakamura, Yuki Kambe, Ryo Fukumori, Kazuhiro Takuma, Kiyofumi Yamada, Takeshi Takarada, Hideo Taniura, Yukio Yoneda
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Journal Title
J Neurosci Res 87
Pages: 2145-2156
Related Report
Peer Reviewed
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[Presentation] ミクログリア細胞における時計遺伝子の発現2008
Author(s)
テルグランヴィア岡山(岡山) [17]山本朋未, 宝田剛志, 佐原甲一, 小椋 正人, 谷浦秀夫, 米田幸雄
Organizer
第113回日本薬理学会近畿部会
Place of Presentation
ホテルグランヴィア岡山(岡山)
Year and Date
2008-06-20
Related Report
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