Analysis of plasticity of cancer cell motility in 3D substrates
| Project/Area Number |
20790254
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kobe University |
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Principal Investigator |
YAMAZAKI Daisuke Kobe University, 大学院・医学研究科, 助教 (50422415)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 癌 / シグナル伝達 / 細胞運動 / 転移 / Rhoファミリー |
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| Research Abstract |
The motility of cancer cells in 3D matrices is of two types : mesenchymal motility, in which the cells are elongated and amoeboid motility, in which the cells are round. Amoeboid motility is driven by an actomyosin-based contractile force, which is regulated by the Rho/ROCK pathway. Here I show that the motility of elongated cells is regulated by Rac signaling through formation of elongated pseudopodia and cell-substrate adhesion.
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Report
(3 results)
Research Products
(6 results)
