| Project/Area Number |
20790259
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Ehime University |
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Principal Investigator |
FUKUDA Shinji Ehime University, 大学院・医学系研究科, 助教 (70398238)
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| Project Period (FY) |
2008 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 分子腫瘍学 / 膜型増殖因子 / がん幹細胞 / 細胞周期 / 癌 / シグナル伝達 / 発現制御 / 薬剤反応性 |
|---|
| Research Abstract |
Recent studies suggests that tumors arise from cancer stem cells. Here, we focused on a membrane-anchored growth factor, Amphiregulin (AREG), which is thought to be expressed in side-population (SP) of hepatocyte cell line, Huh7. We identified AREG-regulating protein (ARP), whose expression is also detected in Huh7 SP. ARP promotes the production of soluble AREG (N-terminal fragment of AREG), thus might be involved in the cell cycle regulation of hepatocyte stem cell regulation.
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