| Project/Area Number |
20790264
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Osaka Bioscience Institute |
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Principal Investigator |
HIKIDA Takatoshi Osaka Bioscience Institute, システムズ生物学部門, 研究員 (70421378)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 分子病態学 / 大脳基底核 / 神経回路 / 薬物依存 / トランスジェニックマウス |
|---|
| Research Abstract |
To explore molecular pathophysiology of drug addiction in the basal ganglia network, we developed a reversible neurotransmission blocking technique, in which transmission of the direct and indirect pathways was selectively and reversibly blocked. The results indicated that the coordinated modulation of these two pathways was necessary for acute psychostimulant actions. This modulation, however, shifted to the predominant roles of the direct pathway in the development of drug addiction by repeated exposure of psychostimulants and rewarding learning and the indirect pathway in aversive learning.
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