| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Research Abstract |
Human cells have evolved multiple safeguard mechanisms to prevent aberrant cell growth. We have identified the novel "p53-Notchl" pathway and pointed out its tumor suppressive role. We revealed how it is disrupted in cancer cells. Particularly, the p53 family member, p63, is found to inhibit both p53-dependent and -independent induction of the Notchl tumor suppressor gene directly through the identified p53-responsive element, thereby maintaining the proliferative capacity of epithelial cells.
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