Disruption of the p53-Notchl pathway in the development of human epithelial cancers
| Project/Area Number |
20790265
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pathological medical chemistry
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| Research Institution | National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East |
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Principal Investigator |
YUGAWA Takashi National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所, 研究員 (80311372)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 分子腫瘍学 / 発がん / がん抑制遺伝子 / 転写調節 / ゲノム傷害 / 細胞分化 |
|---|
| Research Abstract |
Human cells have evolved multiple safeguard mechanisms to prevent aberrant cell growth. We have identified the novel "p53-Notchl" pathway and pointed out its tumor suppressive role. We revealed how it is disrupted in cancer cells. Particularly, the p53 family member, p63, is found to inhibit both p53-dependent and -independent induction of the Notchl tumor suppressor gene directly through the identified p53-responsive element, thereby maintaining the proliferative capacity of epithelial cells.
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Report
(4 results)
Research Products
(57 results)
