Lung cancer and Smoking : Effect of cigarette smoke extra on nuclear receptors
| Project/Area Number |
20790271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Human pathology
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| Research Institution | Tohoku University |
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Principal Investigator |
MIKI Yasuhiro Tohoku University, 大学院・医学系研究科, 助教 (50451521)
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| Research Collaborator |
ABE Keiko 東北大学, 大学院・医学系研究科, 助教 (80455782)
SASANO Hironobu 東北大学, 大学院・医学系研究科, 教授 (50187142)
SUSUKI Takashi 東北大学, 大学院・医学系研究科, 教授 (10261629)
AKAHIRA Jun-ichi 東北大学, 大学院・医学系研究科, 助教 (90359505)
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| Project Period (FY) |
2008 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肺癌 / 喫煙 / 核内受容体 / エストロゲン / CYP19 |
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| Research Abstract |
Recently, sex steroid hormones such as estrogen have been considered to play some roles in lung cancer. In this study, we demonstrated that cigarette smoke condensate (CSC) has estrogenic action through the estrogen receptor in vitro. In lung carcinoma patients, a correlation was found between the patients smoking history and CYP19 expression evaluated using quantitative RT-PCR. Results from our study suggested that CYP19 expression might be increased smoking through the cytokine signal. These findings all suggested that smoking might stimulate the estrogen signals directly and /or indirectly in lung carcinoma tissues.
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Report
(3 results)
Research Products
(14 results)
